Long-Term Impact of Military-Relevant Brain Injury Consortium Chronic Effects of Neurotrauma Consortium

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What has LIMBIC-CENC Learned About TBI Outcomes

LIMBIC-CENC has been busy over the last 6 years studying the effects of mild TBI on military Service Members and Veterans. One major challenge is that there is no actual specific test to say for certain if someone has a concussion. Instead the diagnosis is made from talking to the person about the event and the symptoms they have. Obviously, one single way of doing this would be helpful. So, LIMBIC-CENC developed a standard interview form so that all LIMBIC-CENC participants are interviewed the same way each time no matter where or when the study site is located. This LIMBIC-CENC standard interview is available to brain researchers all around the world.

LIMBIC-CENC has learned that mild TBIs are linked with many other conditions. For example, TBIs and PTSD symptoms are often found together. LIMBIC-CENC has been learning how the two are linked (think “chicken and egg”) so that both conditions can be treated better. We are also studying many other conditions that occur to people with TBI to see if they are related.

LIMBIC-CENC scientists have also been looking at markers in the blood and at brain images that may show connections between late-life dementia and TBI. Studies will take more time, but several interesting trends have been seen. Also, we are busy thinking about single versus repeated mild TBIs and how they affect the brain.

None of these exciting projects would be possible without the time and dedication of our participants. We thank you!

For additional information about what LIMBIC-CENC has learned, visit the


Plain Language Abstracts

The U.S. Army Medical Research Acquisition Activity, 839 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, through the Psychological Health/Traumatic Brain Injury Research Program Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award/W81XWH-18-PH/TBIRP-LIMBIC under Awards No. W81XWH1920067 and W81XWH-13-2-0095, and by the U.S. Department of Veterans Affairs Awards No. I01 CX002097, I01 CX002096, I01 HX003155, I01 RX003444, I01 RX003443, I01 RX003442, I01 CX001135, I01 CX001246, I01 RX001774, I01 RX 001135, I01 RX 002076, I01 RX 001880, I01 RX 002172, I01 RX 002173, I01 RX 002171, I01 RX 002174, and I01 RX 002170. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. / Created by VCU University Relations

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