Long-Term Impact of Military-Relevant Brain Injury Consortium Chronic Effects of Neurotrauma Consortium

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In August 2012, President Obama issued an Executive Order to develop a National Research Action Plan (NRAP) to address traumatic brain injury (TBI) as well as post-traumatic stress disorder (PTSD) and other mental health conditions for improved prevention, diagnosis and treatment. An area of particular concern was the high prevalence of mild TBI (mTBI) among veterans of recent military conflicts, including Operation Enduring Freedom (OEF, Afghanistan), Operation Iraqi Freedom (OIF, Iraq), and their follow-on conflicts like Operation New Dawn (collectively OEF/OIF). A combined Departments of Defense (DoD) and Veterans Affairs (VA) competitive consortium grant was created and ultimately awarded to Virginia Commonwealth University (VCU) in 2014.

The mission of the Long-term Impact of Military-relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) is to fill the gaps in knowledge about the basic science of mTBI (also termed concussion or mild TBI), determine its effects on late-life outcomes and neurodegeneration, identify service members most susceptible to these effects, and identify the most effective treatment strategies. LIMBIC-CENC is a multi-center collaboration linking premier basic science, translational, and clinical neuroscience researchers from the DoD, VA, academic universities, and private research institutes to effectively address the scientific, diagnostic, and therapeutic ramifications of mTBI and its long-term effects.

LIMBIC-CENC has a dedicated Knowledge Translation Center tasked with sharing LIMBIC-CENC research results and ongoing findings with our participants as well as military and veteran health care professionals, mTBI researchers and the general public.

The U.S. Army Medical Research Acquisition Activity, 839 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, through the Psychological Health/Traumatic Brain Injury Research Program Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award/W81XWH-18-PH/TBIRP-LIMBIC under Awards No. W81XWH1920067 and W81XWH-13-2-0095, and by the U.S. Department of Veterans Affairs Awards No. I01 CX002097, I01 CX002096, I01 HX003155, I01 RX003444, I01 RX003443, I01 RX003442, I01 CX001135, I01 CX001246, I01 RX001774, I01 RX 001135, I01 RX 002076, I01 RX 001880, I01 RX 002172, I01 RX 002173, I01 RX 002171, I01 RX 002174, and I01 RX 002170. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. / Created by VCU University Relations