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Long-Term Impact of Military-Relevant Brain Injury Consortium Chronic Effects of Neurotrauma Consortium

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Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans

Kennedy, E., Panahi, S., Stewart, I. J., Tate, D. F., Wilde, E. A., Kenney, K., Werner, J. K., Gill, J., Diaz-Arrastia, R., Amuan, M., Van Cott, A. C., & Pugh, M. J. (2022). Traumatic Brain Injury and Early Onset Dementia in Post 9-11 Veterans. Brain injury, 36(5), 620–627. https://doi.org/10.1080/02699052.2022.2033846. PMID: 35125061; PMCID: PMC9187585.

Main Question

Are TBI and TBI-related sequelae associated with emergence of early onset dementia in Post-9/11 Veterans?

Study Findings

This matched case-control study found that epilepsy, self-reported memory problems, TBI, other neurological conditions (e.g., anoxic brain injury, encephalopathy, Parkinson’s disease), cardiovascular disease, and depression were associated with early onset frontotemporal or Alzheimer’s dementia.

Practical Uses

History of TBI, related sequelae such as epilepsy or Parkinson’s disease, and other well-establsihed health conditions are risk factors of early onset dementia.

Clinicians may consider promoting healthy lifestyle behaviors and prevention for cardiovascular disease beginning early in adulthood to reduce disease development and risk for early onset dementia.

For more information on assessing and managing mTBI

In an effort to provide the latest findings to our consumers as quickly as possible, some of these studies, while fully peer reviewed, have not been presented or published either electronically or in print. Findings are presented for informational purposes only and should not be cited or referenced until they are formally published or presented.

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The U.S. Army Medical Research Acquisition Activity, 839 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, through the Psychological Health/Traumatic Brain Injury Research Program Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award/W81XWH-18-PH/TBIRP-LIMBIC under Awards No. W81XWH1920067 and W81XWH-13-2-0095, and by the U.S. Department of Veterans Affairs Awards No. I01 CX002097, I01 CX002096, I01 HX003155, I01 RX003444, I01 RX003443, I01 RX003442, I01 CX001135, I01 CX001246, I01 RX001774, I01 RX 001135, I01 RX 002076, I01 RX 001880, I01 RX 002172, I01 RX 002173, I01 RX 002171, I01 RX 002174, and I01 RX 002170. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. / Created by VCU University Relations

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