Home » Knowledge Translation Center – Old Version – 9/25/2019

Knowledge Translation Center – Old Version – 9/25/2019

The present focus of the CENC Knowledge Translation Center is to review, organize, and summarize results from CENC publications, with the ultimate goal of disseminating information about TBI and military health to the general public, scientists, and clinicians, as an effort to increase awareness. Dr. Ron Seel, Ph.D., Executive Director of the Virginia Commonwealth University (VCU) Center for Rehabilitation Sciences and Engineering (CERSE), is leading CENC Knowledge Translation efforts as the Program Director, leveraging practicing clinical TBI faculty from VCU and Hunter Holmes McGuire VAMC. The CENC Knowledge Translation Center aims to expand awareness about TBI and military health by distributing information through development and continuous refinement of the following items. Click on any item to view additional details and produced materials:

1. Clinical/Scientific Relevance Statements (BLUF)

Development of Clinical/Scientific Relevance Statements from all CENC publications

2. Plain Language Abstracts

Review and dissemination of Plain Language Abstracts developed for all CENC publications
Plain Language Abstracts have been created for the following CENC publications. Each Plain Language Abstract provides a brief publication synopsis which describes the CENC research conducted, results produced, and military impact. Click on any CENC publication title presented to view the Plain Language Abstract:

▪	Association of mild traumatic brain injury with and without loss of consciousness with dementia in US military Veterans
▪	Do postconcussive symptoms from traumatic brain injury in combat Veterans predict risk for receiving opioid therapy for chronic pain?
▪	Default mode network, connectivity, traumatic brain injury and post-traumatic amnesia
▪	Mild traumatic brain injury in soldiers returning from combat
▪	Systems Biology, Neuroimaging, Neuropsychology, Neuroconnectivity and Traumatic Brain Injury
▪	The VA/DoD Chronic Effects of Neurotrauma Consortium: An Overview at Year 1
▪	Chronic effects of neurotrauma consortium: a combined comparative analysis of six studies
▪	Longitudinal evaluation of ventricular volume changes associated with mild traumatic brain injury in military service members
▪	PTSD confounds detection of compromised cerebral white matter integrity in military Veterans reporting a history of mild traumatic brain injury
▪	Understanding the impact of mild traumatic brain injury on Veteran service-connected disability: results from Chronic Effects of Neurotrauma Consortium
▪	Validation of diffusion MRI estimates of compartment size and volume fraction in a biomimetic brain phantom using a human MRI scanner with 300mT/m maximum gradient strength
▪	Negative impact of female sex on outcomes from repetitive mild traumatic brain injury in hTau mice is age dependent: A chronic effects of neurotrauma consortium study
▪	Mild TBI and risk of Parkinson’s disease: A Chronic effects of neurotrauma consortium study
▪	Exploring the factor structure of a battery of neuropsychological assessments among the CENC cohort
▪	The role of pain catastrophizing in cognitive functioning among veterans with history of mild traumatic brain injury
▪	Pain and chronic mild traumatic brain injury in the US military population: a Chronic Effects of Neurotrauma Consortium study
▪	Advanced neuroimaging to quantify myelin in vivo: Application to mild TBI
▪	Dementia after moderate-severe traumatic brain injury: Coexistence of multiple proteinopathies
▪	Higher exosomal phosphorylated tau and total tau among veterans with combat-related repetitive chronic mild traumatic brain injury
▪	Chronic cerebrovascular abnormalities in a mouse model of repetitive mild traumatic brain injury
▪	Early Clinical Predictors of 5-year Outcome after Concussive Blast Traumatic Brain Injury
▪	Longitudinal changes in neuroimaging and neuropsychiatric status of post-deployment Veterans: A CENC pilot study
▪	Repetitive head impacts and chronic traumatic encephalopathy
▪	Distress tolerance and symptom severity mediate failure on a symptom validity test in Iraq and Afghanistan Veterans with PTSD
▪	Impact of age on acute post-TBI neuropathology in mice expressing humanized tau: A chronic effects of neurotrauma consortium
▪	Gene profiling of nucleus basalis tau containing neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study
▪	Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A Chronic Effects of Neurotrauma Consortium study
▪	Functional brain connectivity and cortical thickness in relation to chronic pain in post-911 veterans and service members with mTBI
▪	Phospholipid disruption in the brain links mouse models of repetitive mild traumatic brain injury and alzheimer’s disease
▪	Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers
▪	Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment
▪	A retrospective cohort study of comorbidity trajectories associated with traumatic brain injury in veterans of the Iraq and Afghanistan wars
▪	Comparing two processing pipelines to measure subcortical and cortical volumes in patients with and without traumatic brain injury
▪	Increased small-world network topology following deployment-acquired traumatic brain injury associated with the development of post-traumatic stress disorder
▪	Association of Traumatic Brain Injury with Chronic Pain in Iraq and Afghanistan Veterans: Impact of Comorbid Mental Health Conditions
▪	Traumatic Brain Injury and Receipt of Prescription Opioid Therapy for Chronic Pain in Iraq and Afghanistan Veterans: Do Clinical Practice Guidelines Matter?
▪	Recruiting for a multicentre DoD and VA longitudinal study: lessons learned
▪	Supervised learning technique for the automated identification of white matter hyperintensities in traumatic brain injury
▪	Sensory dysfunction and traumatic brain injury severity among deployed post-9/11 Veterans: A Chronic Effects Of Neurotrauma Consortium study
▪	Prevalence of hearing loss and tinnitus in Iraq and Afghanistan Veterans: A Chronic Effects of Neurotrauma Consortium study
▪	Assessing the Structural and Functional Effects of Neuromodulation Using Magnetic Resonance Imaging
▪	Susceptibility Weighted Imaging and White Matter Abnormality Findings in service members With Persistent Cognitive Symptoms Following Mild Traumatic Brain Injury
▪	Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury
▪	Inflammatory changes in optic nerve after closed-head repeated traumatic brain injury: Preliminary study.
▪	Repeated Concussions: Time to Spur Action Among Vulnerable Veterans
▪	Is balance performance reduced after mild traumatic brain injury?: Interim analysis from chronic effects of neurotrauma consortium (CENC) multi-centre study
▪	The Chronic Effects of Neurotrauma Consortium (CENC) multi-centre study interim analysis: Differences between participants with positive versus negative mild TBI histories.
▪	The Chronic Effects of Neurotrauma Consortium (CENC) multi-centre observational study: Description of study and characteristics of early participants.
▪	Characterizing effects of mild traumatic brain injury and posttraumatic stress disorder on balance impairments in blast-exposed servicemembers and Veterans using computerized posturography
▪	Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits
▪	Quantitative structural neuroimaging of mild traumatic brain injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of volumetric data within and across scanners

3. Postcards

Development of Postcards using plain language abstracts
The following Postcards offer summaries about TBI and associated impacts, as well as military health. Click on any topic presented to view a Postcard that provides explanation and pertinent information:

▪	Mild TBI and Brain Health
▪	Mild TBI and Veterans Disability
▪	Blast-related Mild TBI and Disability
▪	Patterns of Veterans Health Outcomes
▪	The Effect of Mild TBI on Balance
▪	Association between TBI and Pain
▪	Relationship between TBI and Pain
▪	Opioid Therapy for Chronic Pain after TBI
▪	Dementia Risk in Veterans with TBI
▪	Risk of Parkinson’s Disease in Veterans with TBI
▪	CTE and Genetic Profiling

4. Online, Self-Paced Course

Development of Online, Self-Paced Course from 15 clinically meaningful CENC publications

5. CENC Scientific Bibliography

Updating and annotation of a CENC Scientific Bibliography to include all available abstracts, articles and presentations by CENC researchers from 2013-present

6. Social Media Platform

Continuous updating of the CENC Social Media Platform, as well as the new CENC website, to disseminate #’s 1-5 above
Follow CENC on Facebook, Twitter, and Instagram by clicking on the links provided below (CENC Social Media pages are additionally accessible through the icons presented within the Footer, at the bottom-right corner of all CENC website pages):

▪	Facebook
▪	Twitter
▪	Instagram

7. Assessment Tools

Development of a comprehensive Assessment Tools section
The following section includes Assessment Tools employed for CENC research data collection. Click on any Assessment Tool presented to view the document:

▪	Potential Concussive Event (PCE) Mapping Interview Form
▪	Potential Concussive Event (PCE) Mapping tables
▪	Potential Concussive Event (PCE) Mapping Algorithm Diagram
▪	Retrospective Concussion Diagnostic Interview Form