Long-Term Impact of Military-Relevant Brain Injury Consortium Chronic Effects of Neurotrauma Consortium

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LIMBIC-CENC Cycle 2, 2019-2023

The U.S. Department of Veterans Affairs (VA) and the Department of Defense (DOD) launched the Long-Term Impact of Military-related Brain Injury Consortium (LIMBIC) Oct. 1, for which the two organizations pledged to fund up to $50 million, to research mild traumatic brain injuries (TBI) or concussions.

Studies


Principal Investigator Contact Information
Dr. William Walker, M.D. william.walker@vcuhealth.org

Study description: The Prospective Longitudinal Study aims to continue the research successfully conducted during CENC Cycle 1, as well as expand the current active cohort of 1,500 Service Members and Veterans. Throughout the duration of CENC Cycle 2, the Prospective Longitudinal Study will refine methods, enhance analyses, and apply results to identify predictors and longitudinal effects of mTBI.

If you are a Service Member or Veteran interested in being a participant for this study, click on the following link for additional information: Participate in CENC Research.


Principal Investigator Contact Information
Dr. Kristine Yaffe, M.D. Kristine.Yaffe@ucsf.edu

Study description: The Retrospective Database Study aims to maintain, augment, and refine the database of 1.6 million Veterans, created during CENC Cycle 1, as well as expand analyses and application of results. During CENC Cycle 2, the Retrospective Database Study will conduct analyses to identify, examine, and elucidate outcome predictors, comorbidities, and neurodegenerative sequelae associated with mTBI, ultimately aiming to apply results to development of prognostic models.


Principal Investigator Contact Information
Dr. Mary Jo Pugh, Ph.D., RN MaryJo.Pugh@hsc.utah.edu

Study description: The Phenotypes Study


Principal Investigator Contact Information
Clara E. Dismuke, Ph.D. Clara.Dismuke@va.gov

Study description: The Health Economics Study


Principal Investigator Contact Information
Elisabeth A. Wilde, Ph.D. elisabeth.wilde@hsc.utah.edu

Study description: The Novel Neuroimaging Study


Principal Investigators Contact Information
Kimbra Kenney, M.D., Jessica Gill Ph.D., and Kevin Wang Ph.D. elisabeth.wilde@hsc.utah.edu, gillj@mail.nih.gov

Study description: The Biomarkers Discovery Study

Cores


Location Website
Virginia Commonwealth University, https://www.vcu.edu/
Richmond, VA

Core description: The Coordinating Center manages and provides support for all consortium activities. Through individual and collective collaboration with CENC leadership, Core Directors, and Study personnel, the Coordinating Center ensures regulatory compliance, monitors progress, facilitates communication, and offers assistance, in order to promote success for each project, as well as the unified consortium.


Location Website
Hunter Holmes McGuire Veterans Affairs Medical Center, & https://www.richmond.va.gov/
Virginia Commonwealth University, https://www.vcu.edu/
Richmond, VA
VA Salt Lake City Health Care System, & https://www.saltlakecity.va.gov/
University of Utah, https://www.utah.edu/
Salt Lake City, UT

Core description: The Data and Biostatistics Core centrally and securely maintains all consortium data, provides biostatistical support, assists with study design functions, conducts data processing, and performs biostatistical analyses for manuscripts and presentations.


Location Website
Uniformed Services University of the Health Sciences, https://www.usuhs.edu/
Bethesda, MD

Core description: The Biomarkers Core manages the transfer, storage, and processing of all blood and saliva samples collected, for all consortium projects that conduct biospecimen collection procedures.


Location Website
VA Salt Lake City Health Care System, & https://www.saltlakecity.va.gov/
University of Utah, https://www.utah.edu/
Salt Lake City, UT

Core description: The Neuroimaging Core facilitates acquisition, review, transfer, collation, tracking, analysis, reporting, storage, and interpretation of neuroimaging data, for all consortium projects that conduct imaging procedures.

The U.S. Army Medical Research Acquisition Activity, 839 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. This work was supported by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, through the Psychological Health/Traumatic Brain Injury Research Program Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award/W81XWH-18-PH/TBIRP-LIMBIC under Awards No. W81XWH1920067 and W81XWH-13-2-0095, and by the U.S. Department of Veterans Affairs Awards No. I01 CX002097, I01 CX002096, I01 HX003155, I01 RX003444, I01 RX003443, I01 RX003442, I01 CX001135, I01 CX001246, I01 RX001774, I01 RX 001135, I01 RX 002076, I01 RX 001880, I01 RX 002172, I01 RX 002173, I01 RX 002171, I01 RX 002174, and I01 RX 002170. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. / Created by VCU University Relations